This solved my problem too

This is an excellent tip!

I don't run parallels, nor do I have any other of the configurations that are commonly being listed in the forums as possible causes for this error. But I still couldn't run Cisco VPN client (any version up to 4.9.01 (0080)) no matter what I tried. The infamous Error 51 kept popping up.

This tip fixed it. Thank you so much!

Mark

PS: for the PICO challenged: if you happen to have BBEdit: just type
sudo bbedit /System/Library/StartupItems/CiscoVPN/CiscoVPN
in the terminal to open the file in BBEdit.

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